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- W2355480543 abstract "Objective To provide an ideal animal model for exploring the pathogenesis and experimental treatment of malignant lymphoma of small intestine. Methods Fresh lymphoma tissues of primary lesions and liver metastatic lesions from the patients with small intestinal malignant lymphoma were respectively transplanted into mucosa of the small intestine and subcutaneous part of the interscapular region in nude mice. Tumorgenecity,invasion and metastasis of transplanted tumors were observed. Morphology(light microscopy,electron microscopy and immunohistochemistry),karyotype analysis,DNA quantitative assay(FCM) were also studied. Results In five cases of small intestinal malignant lymphoma,transplantation was successfully performed in three cases. A strain of high metastasis was screened from the models of Non-Hodgkin’s lymphoma (B cell) derived from the identical human small intestinal identical lymphoma. Orthotopically transplanted and subcutaneously transplanted models were named HSIL-0101 and HSIL-0102 respectively. Histopathology of transplanted tumor showed high-grade large B-cell lymphoma, CD19,CD20,CD22 and CD45 positivity, and CD3 and CD7 negativity. The number of chromosome was between 55 and 59. DNA Index (DI) was 1.47～1.61(ie,heteroploid). HSIL-0101 and HSIL-0102 were passaged for 32 and 38 generations in nude mice separately. 357 nude mice were used for transplantation. The growth rate of the transplanted neoplasm and resuscitation rate of liquid nitrogen cryopreservation were both 100%. In HSIL-0101, liver and lymph node metastasis rates were both 100%. In HSIL-0102, liver metastasis rate was 63.5%and lymph node metastasis rate was 62.7%. The transplanted tumors invasively grew in small intestine and subcutaneous part of the nude mice, and led to blood metastasis(liver and spleen metastases),lymph metastasis and seeding metastasis in abdominal cavity. Conclusions This study is the first time to successfully establish spontaneous high metastasis models of malignant lymphoma of human small intestine in nude mice by orthotopic and subcutaneous transplantation. HSIL-0101 and HSIL-0102 can be used to perform research on pathogenesis,invasion,metastasis,and experimental therapy of malignant lymphoma of small intestine." @default.
- W2355480543 created "2016-06-24" @default.
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- W2355480543 date "2004-01-01" @default.
- W2355480543 modified "2023-09-25" @default.
- W2355480543 title "High metastasis models of malignant lymphoma of human small intestine established in nude mice by orthotopic and subcutaneous transplantation" @default.
- W2355480543 hasPublicationYear "2004" @default.
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