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- W2355492057 abstract "Objective To investigate the effects of platelet-derived growth factor BB (PDGF-BB)on proliferation of human umbilical vein endothelial cells, rabbit vascular smooth muscle cells and human vascular fibroblasts. Methods The human umbilical vein endothelial cells, rabbit vascular smooth muscle cells and human vascular fibroblasts were cultured. Effects of PDGF-BB on DNA synthesis of the three kinds of cells were studied using 3H-TdR incorporation in vitro. Results PDGF-BB significantly accentuated DNA synthesis of quiescent human vascular fibroblasts, rabbit vascular smooth muscle cells and human umbilical vein endothelial cells in a dose-dependent manner, with a maximal response of fibroblasts at a concentration of 30 ng/ml and vascular smooth muscle cells and endothelial cells at a concentration of 40 ng/ml. The maximal response was induced by a concentration of 30 ng/ml at 24 h, 36 h and 48 h respectively. Conclusion PDGF-BB promote proliferation of cultured human umbilical vein endothelial cells, rabbit vascular smooth muscle cells and human vascular fibroblasts." @default.
- W2355492057 created "2016-06-24" @default.
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- W2355492057 date "2003-01-01" @default.
- W2355492057 modified "2023-09-23" @default.
- W2355492057 title "Effects of Platelet-derived Growth Factor BB on Proliferation of Human Vascular Endothelial Cells,Rabbit Vascular Smooth Muscle Cells and Human Vascular Fibroblasts" @default.
- W2355492057 hasPublicationYear "2003" @default.
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