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- W2355492080 abstract "Objective To investigate the expression of apoptosis related genes, Survivin, bcl 2 and bax in apoptosis of MDS cell line MUTZ 1, and possible mechanisms of homoharringtonine (HHT) in the treatment of myelodysplastic syndrome (MDS). Methods The apoptosis of MDS RAEB cell line MUTZ 1 was observed by transmission electron microscope. Cell apoptosis and cell cycle shift were also investigated by flow cytometry (FCM).The expression of Survivin, bcl 2 and bax was detected by retrotranscriptase polymerase chain reaction (RT PCR). Results Apoptotic peak on FCM and positive Annexin V FITC on cell membrane showed that HHT induced apoptosis of MUTZ 1 cell in a dose and time dependent manner. HHT significantly down regulated Survivin expression, but there were no changes on bax and bcl 2 expression. Conclusion HHT could induce apoptosis of MDS cell line(MTUZ 1) and Survivin might play an important role in MDS." @default.
- W2355492080 created "2016-06-24" @default.
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- W2355492080 date "2003-01-01" @default.
- W2355492080 modified "2023-09-27" @default.
- W2355492080 title "Involvement of apoptosis-related gene Survivin, bcl-2 and bax in the homoharringtonine-induced apoptosis of myelodysplastic syndrome cell line(MUTZ-1)" @default.
- W2355492080 hasPublicationYear "2003" @default.
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