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- W2355496750 abstract "Objective To assess and detect the diagnostic significance of anti-CCP, anti-RA54, anti-Sa antibody and rheumatoid factor in rheumatoid arthritis patients. Methods Anti-CCP antibody were deteceted with ELISA, anti-RA54 antibody and anti-Sa antibody were examined with western blotting, and rheumatoid factor was deteceted with immunoturbidimetric assay in 116 patients with rheumatoid arthritis. Results (1)The specificities and sensitivities of anti-CCP, anti-RA54, anti-Sa antibody and rheumatoid factor were 93. 9% and 41. 4%, 90. 9% and 30. 2%, 92. 4% and 36.2%, 77. 3% and 49. 1%. There were no statistic differences in the specificity between the three antibody groups and rheumatoid factor until 1 : 128 was taken as positive titer. Among 59 patients with RF negative rheumatoid arthritis, 16(27. 1%) were positive for anti-CCP, 14(23. 7%) positive for anti RA54 and 19(32. 2%) positive for anti-Sa antibody. (2) The specificity and sensitivity were 98. 5% and 46. 6% respectively when two of the four antibodies turned out to be both positive. If three or more kinds were detected simultaneously, the specificity was 100%. Conclusion Detection of anti CCP, anti-RA54, anti-Sa antibody and rheumatoid factor can greatly improve the specificity of the diagnosis of early rheumatoid arthritis." @default.
- W2355496750 created "2016-06-24" @default.
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- W2355496750 date "2005-01-01" @default.
- W2355496750 modified "2023-09-24" @default.
- W2355496750 title "Detection and significance of the anti-CCP antibody, anti-RA54, anti-Sa antibody and rheumatoid factor in patients with rheumatoid arthritis" @default.
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