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- W2355514097 abstract "Objective To investgate heme oxygenase-2 gene deletion decreasing oxidative stress injury induced by heme in vivo.Methods Stereotactic injection of 6 μ l of a sterile hemin (8 μmol/L) into the striatum of wild type and HO-2 knock out mice. Cell viability, protein oxidation, and lipid oxidation of the striatum were determined after 72 h injection. Western blot analysis was applied for heme oxygenase-1 (HO-1) measurement.Results Protein oxidation and lipid oxidation decreased significantly in HO-2 knockout mice at 72 h compared with that of wild-type mice. Striatal cell viability increased significantly in knockout mice at 72 h compared with that of wild-type mice. HO-1 expression at baseline and 72 h after hemin injection was also similar to that of wild-type mice.Conclusion These results suggest that HO-2 gene deletion protects neurons from heme mediated oxidative stress injury. Selective inhibition of neuronal HO-2 may have a beneficial effect on oxidative stress-induced neuronal injury." @default.
- W2355514097 created "2016-06-24" @default.
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- W2355514097 date "2005-01-01" @default.
- W2355514097 modified "2023-09-23" @default.
- W2355514097 title "Protective role of heme oxygenase-2 gene deletion in oxidative stress-induced brain injury" @default.
- W2355514097 hasPublicationYear "2005" @default.
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