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- W2355527749 abstract "Objective To investigate the relationship between serotonin receptor-la and the mechanism of IFN-in-duced depression, and the role of prophylactic use of antidepressants in IFN-induced depression. Methods Jurkat cells were treated with 300ng/ml doses of IFN for 1 ,2 ,3 d. The Jurkat cells treated with 300 ng/mL IFN for 3 d were then separated into two groups: one group treated with IFN for additional 3 d and the other was not treated with IFN but observed 3 d. Jurkat cell was treated with 300 ng/mL doses of IFN alone or co-incubated with antidepressant ( fluoxetine) for 3 d. The protein expression and mRNA level of serotonin receptor-1a were analyzed by Western blot, RT-PCR and quantitative real-time RT-PCR. Results The time-dependent decreases of protein expression and mRNA level of serotonin receptor-la were observed. Partial recovery was observed following IFN withdrawal. Co-incubation with antidepressant (fluoxetine) attenuated the effect of IFN on serotonin receptor-1a. Conclusion The decrease of serotonin receptor-1a is one of the mechanisms of IFN-induced depression. Prophylactic use of fluoxetine might prevent and treat the development of IFN-induced depression." @default.
- W2355527749 created "2016-06-24" @default.
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- W2355527749 date "2005-01-01" @default.
- W2355527749 modified "2023-09-28" @default.
- W2355527749 title "Role of Serotonin Receptor-la in Interferon-Induced Depression" @default.
- W2355527749 hasPublicationYear "2005" @default.
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