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- W2355529636 abstract "Objective To study the expression of cyclooxygenase2 in hepatic inflammatory reaction of rats with sepsis and its effect on metabolism.Methods Fifty-four Wistar rats were randomly divided into 3 groups:Sham(A)group,sepsis model(B)group,and NS398 intervention(C)group.The rats were subjected to cecal ligation and puncture(CLP)for sepsis model or sham operation.RT-PCR was used to determine COX-2 mRNA expression,serum prealbumin(PA)and transferrin(TF)by radioimmunity.At the same time,ALT,AST,albumin determination and liver pathological changes were determined.Results(1)The expression of COX-2 mRNA was low in A group,higher in B and C groups,and higher in B than C group at each time period(P0.05);(2)Serum ALT and AST were markedly increased in B than in A and C groups(P0.05);(3)Pathologic ally,hepatic injury was severe in B group,but mild in C group;(4)The levels of PA,IF and Ab were higher in A group than in B and C groups,but was lower in B group than C group(P0.05).Conclusions COX-2 plays an important role of hepatic injury in sepsis,and can promote catabolism and inhibit anabolism.The selective cox-2 inhibitor,NS398,can effectively protect hepatic cell in sepsis and attenuate albuminolysis." @default.
- W2355529636 created "2016-06-24" @default.
- W2355529636 creator A5053969245 @default.
- W2355529636 date "2009-01-01" @default.
- W2355529636 modified "2023-09-25" @default.
- W2355529636 title "Effect of cyclooxygenase-2 on hepatic injury and metabolism in rats with sepsis" @default.
- W2355529636 hasPublicationYear "2009" @default.
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