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- W2355534480 abstract "Objective: To explore the mechanism of EGb761-mediated neuroprotection in ischemia rat.Methods: Rats were delivered with EGb761(50 mg/kg and 100 mg/kg) orally for 10 days before occluding the brain middle artery,then rats were killed and their brains were obtained.Being used TTC staining,immunohistochemisty and western blot techniques,there were some indices compared such as the brain histology injury and the level of Caspase-3,Caspase-9,and p38/P-P38,MEK/P-MEK and ERK / P-ERK in brain tissues.Results: EGb761 reduced the brain infarct volume and significantly inhibited the caspase-3 expression in ischemic penumbra area.Expressions including P-P38,P-MEK and P-ERK expression were decreased in the penumbra of ischemic rats after being treated with EGb761.Conclusion: EGb761 effectively reduces the neuronal apoptosis in ischemic rat brain.Its neuroprotection is through inhibition of intrinsic apoptosis pathway and activation of P38 and MEK/ERK." @default.
- W2355534480 created "2016-06-24" @default.
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- W2355534480 date "2012-01-01" @default.
- W2355534480 modified "2023-09-26" @default.
- W2355534480 title "Mechanism of Neuroprotective Effect in EGb761 on Rats with Cerebral Ischemia Injury" @default.
- W2355534480 hasPublicationYear "2012" @default.
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