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- W2355542801 abstract "Objective To evaluate the effects of pentoxifylline(PTX) on the changes of histology of DRGs and pain related behaviors after nucleus pulposus was implanted to DRGs.Methods Autologous nucleus pulposus was applied to the peripheral of the L 4 and L 5 d DRG .Based on this animal model,Von Frey filaments and a thermal testing device (RTX 1 type) were used to quantify behavior test.Hemattoxylin and eosin staining,Toluidne blue staining and electron microscope was used to observe the histologic changes of DRGs.By a epidurale catheter PTX was injected into the positon of the L 4 and L 5 DRGs,the changes of hitologic and pain related behaviors were recorded.Results Peripheral applying of the nucleus pulpusus to nerve root and DRG caused mechanical allodynia,but thermal hyperalgesia was not oberserved.Significant endoneurial edema,inflammation reaction and demyelination can be seen in the DRGs and nerve roots.PTX could diminish the inflammation reaction and improve the degree of mechanical allodynia.Conlusions PTX,as a anti TNF α drug,could diminish the degree of mechanical allodynia caused by topical application of NP,which suggested that anti inflammatory cytokine therapy,especially to TNF α,may become an effective treament of sciatica due to disc herniation." @default.
- W2355542801 created "2016-06-24" @default.
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- W2355542801 date "2004-01-01" @default.
- W2355542801 modified "2023-09-25" @default.
- W2355542801 title "The effect of pentoxifylline on the changes of histology and pain related behavior caused by auto-transplantation of nucleus pulposus to DRGs" @default.
- W2355542801 hasPublicationYear "2004" @default.
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