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- W2355552134 abstract "Object To observe the effect of melittin on the growth and proliferation of H 22 hepatocarcinoma cells and study the possible mechanisms. Methods The proliferation inhibitory rate of H 22 cells treated with melittin was assayed by MTT. The volume of proliferating cell nuclear antigen (PCNA) expression of H 22 cells treated with melittin was analyzed with flow cytometer after being stained with immunocytochemical methods. The antitumor effect of melittin was observed in H 22 tumor burdened mice. Results The H 22 cell killing by melittin was dose dependent. After treatment with melittin, the fluorescence density of PCNA of H 22 cells decreased significantly. Melittin can inhibit the growth of H 22 hepatocarcinoma in vivo. Conclusion Melittin can inhibit the proliferation of H 22 cells both in vitro and in vivo. Down regulating the expression of PCNA of cells may be one of antitumor mechanisms." @default.
- W2355552134 created "2016-06-24" @default.
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- W2355552134 date "2003-01-01" @default.
- W2355552134 modified "2023-09-25" @default.
- W2355552134 title "Effect of melittin on growth and proliferation of H_(22) hepatocarcinoma cells" @default.
- W2355552134 hasPublicationYear "2003" @default.
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