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- W2355556463 abstract "[Objective] The expression of CD62P and CD44 in the kidney tissue of IgA nephropathy (IgAN) children were detected to investigate the relationship between the expression of CD62P and CD44 with the tubulointerstitial damages and their role in the occurrence and development of children IgAN. [Methods] Forty-six IgAN children were subjected to 3 groups by their clinical features: simple hematuria group (14 patients), hematuria and proteinuria group (17 patients), nephritic syndrome group (15 patients). These patients were also divided into three groups according to their pathologic grading: grade Ⅰ+Ⅱ(23 patients), grade Ⅲ(14 patients), grade Ⅳ (9 patients). The healthy control group included 4 biopsy species. The expressions of CD62P and CD44 in kidney tissue were detected by immunohistochemistry. [Results] (1)CD62P and CD44 could only be found little expression in normal kidney, whereas, in kidney tissue of children IgAN, CD62P was highly expressed in tubuli, and CD44 was wildly expressed in glomeruli, tubuli, and interstitium. (2)The expression of both CD62P and CD44 were higher in kidney tissue of IgAN children than those in control, which were highly correlated with the clinical features and pathologic changes of the IgAN kidney. In various clinical features groups, there were the highest expression in the group of patients with nephritic syndrome, and the lowest expressions in the group of patients with simple hematuria. (3)The expression of CD62P and CD44 in kidney of IgAN children were positively correlated with the tubulointerstitial injury. [Conclusion] CD62P and CD44 might play an important role in the occurrence and the tubulointerstitial damage of children with IgAN, which were associated with the progression and prognosis in IgAN children." @default.
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- W2355556463 date "2008-01-01" @default.
- W2355556463 modified "2023-09-24" @default.
- W2355556463 title "Expression and Clinical Significance of CD62P and CD44 in Children with IgA Nephropathy" @default.
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