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- W2355560147 abstract "The study was conducted to investigate the effect of Ochratoxin A(OTA) on proliferation,survive,structure and function index,and the antioxidant defense system of jejunum epithelial cells(IPEC-J2 cells).Results showed that exposure time,concentration of OTA and their interaction reduced cell survival rate(P0.01).After 24 h exposure of OTA,the Na+,K+-ATPase,GPx and GST activities and total antioxidant capacity of cells all linearly or quadraticly decreased with the increasing concentration of OTA(P0.01),and the content of MDA was increased linearly(P0.05).Extracellular lactate dehydrogenase activity was increased linearly or quadraticly with the increasing concentration of OTA(P0.01).There was no significant effect of OTA on superoxide dismutase activity(P0.05).In summary,OTA impaired the integrity of structure and function in IPEC-J2 cell,leading to reduction of cell proliferation or survival,and oxidative stress may be an important mechanism of its toxicity." @default.
- W2355560147 created "2016-06-24" @default.
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- W2355560147 date "2011-01-01" @default.
- W2355560147 modified "2023-09-24" @default.
- W2355560147 title "Effect of Ochratoxin A on Proliferation and Redox Balance of IPEC-J2 Cells" @default.
- W2355560147 hasPublicationYear "2011" @default.
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