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- W2355561386 abstract "Objective To study the effect of endomorphin(EM) on dynamic changes of cathartic colon and investigate the pathogenesis of slow transit constipation. Methods An experimental rat model of cathartic colon was established by feeding contract laxative. The effect of endomorphin on muscle strips was studied by the electrical stimulation test in vitroResults Compared to control group,EM-1,EM-2 significantly inhibited the contractile response of muscle strips in cathartic colon of rats in vitro to electrical stimulation in concentration-dependent manner, the amplitude of contractile wave decreased markedly, especially in distal colon .The effect of EM-1 was more pronounced than that of EM-2,which was reversed by the MOR antagonist naloxone in concentration-dependent manner.Conclusion EM may be involved in the disorder of intestine motility of cathartic colon,and could be an important pathological factor of STC." @default.
- W2355561386 created "2016-06-24" @default.
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- W2355561386 date "2005-01-01" @default.
- W2355561386 modified "2023-09-24" @default.
- W2355561386 title "Effect of Endomorphin on Contractile Response of Colon Muscle Strips in Cathartic Colon Rats in Vitro" @default.
- W2355561386 hasPublicationYear "2005" @default.
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