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- W2355562844 abstract "Objective To study the role of inactivation of p53Arg protein and p53Pro protein and aberrant regulation of cell cycle in the mechanism of HPV-related cervical cancer.Methods The expression of CyclinD1,Cdk4,phosphorylation of Rb and Ki-67(PI) were detected by immunohistochemistry.Results The expressions of CyclinD1,Cdk4,high phosphorylation rate of Rb and PI values in cervical cancer of p53 negative group were higher than those in the control group(χ2=16.878,P0.01;χ2=21.120,P0.01;χ2=40.36,P0.01;t=30.53,P0.01).The expressions of CyclinD1 and Cdk4,phosphorylation of Rb showed a positive correlation(P0.01).The PI values in phosphorylation Rb positive group was higher than that in the negative group(P0.05).The expression of CyclinD1 and PI values of p53Pro genotype were higher than those of the p53Arg and p53Pro/Arg genotype(P0.05).Conclusions HPV positive cervical cancer shows part of p53 protein are negatively expressed,which indicates that the p53 protein is degraded by E6 protein.The high PI values in the p53 protein negatively expressed cervical cancer tissues is related to the CyclinD1-Cdk4-Rb pathway.p53Pro protein has stronger abiliy to arrest cell cycle than p53Arg protein." @default.
- W2355562844 created "2016-06-24" @default.
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- W2355562844 date "2011-01-01" @default.
- W2355562844 modified "2023-09-25" @default.
- W2355562844 title "Study on correlation between expression of cell cycle regulation protein and p53Arg72Pro polymorphisms in HPV-associated cervical cancer" @default.
- W2355562844 hasPublicationYear "2011" @default.
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