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- W2355570778 abstract "AIM To study the protective role of somatostatin and growth hormone on systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS) in acute necrotizing pancreatitis (ANP), and evaluate the procession from SIRS to MODS and therapeutic strateqies in ANP.METHODS Rat ANP models were made by retrograde injection of 35 g/ L sodium taurocholate 2 .5 mL/ kg into the pancreatic duct. Serum IL-8, IL-6, TNFα, amylase,endotoxin, and albumin were examined. The morphology and pethology of the pencreas, liver, lung, heart, and kidney as well as the electronmicroscopical investigation of liver, lung and heart cells were observed. Finally TNFαmRNA in the liver, lung, kidney and heart after ANP were oberved by reverse transcriptase-polymerse chain reaction, and TNFαof lung, pancreas, and heart were performed by immunohistochemical staining. Efficiency of somatostatin and growth hormone were also oberved in this experiments.RESIJLTS ANP developed with remarkable elevation of inflammatory mediators which are positively correlated with the development of ANP and MODS, indicating that the liver may play an important role in protecing the host from multiple organ failure.CONCLUSION TNFαmRNA has an important role in ANP progression and somatostatin and growth hormone may be the effedtual treatment to prevent the development and progression of MODS in ANP." @default.
- W2355570778 created "2016-06-24" @default.
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- W2355570778 date "1998-01-01" @default.
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- W2355570778 title "Somatostatin and growth hormone protection on multiple organ injury in acute necrotizing pancreatitis" @default.
- W2355570778 hasPublicationYear "1998" @default.
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