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- W2355572041 abstract "Objective To explore the relationship between the apoptotic rate of tubular epithelial cells and the protein expression levels of Bcl-2 and Bax proteins in delayed graft function(DGF) and discussed its correlation with pathogenic mechanism of DGF.Methods 63 patients suffered from DGF in 586 patients who received the allograft renal transplantation were used as DGF group,the observation values were detected in DGF and recovery periods.10 cases of normal renal function after transplantation were used as control group.The apoptotic rate was determined by TUNEL using pathologic slide of biopsy tissue,and the expression levels Bcl-2 and Bax proteins were detected by immunohistochemistry.Results The apoptotic rate of tubular epithelial cells in DGF group was greatly higher than that in normal control group(P0.01);the Bcl-2 protein expression was decreased and Bax protein expression was increased in DGF group,there were significant differences compared with control group(P0.05,P0.001);the Bcl-2/Bax ratio was decreased,and the apoptotic rate of tubular epithelial cells had negative correlation with Bcl-2 protein expression(r=-0.52,P0.05),and had positive correlation with Bax protein expression(r=0.63,P0.05);the apoptotic rate of tubular epithelial cells in patients in recovery period had no correlation with the expressions of Bcl-2 and Bax.Conclusion The apoptotic rate of tubular epithelial cells of transplant kidney in DGF patients is increased,it is related to the expression of Bcl-2 protein.It suggests that the apoptosis of tubular epithelial cells may take part in the processes of the pathologic injury of DGF." @default.
- W2355572041 created "2016-06-24" @default.
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- W2355572041 date "2010-01-01" @default.
- W2355572041 modified "2023-09-26" @default.
- W2355572041 title "Apoptosis of tubular epithelial cells and expressions of Bcl-2 and Bax proteins in delayed graft function patients" @default.
- W2355572041 hasPublicationYear "2010" @default.
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