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- W2355572575 abstract "Objective To evaluate the bioequivalence of mecobalamin soft capsules in healthy volunteers. Methods Twenty healthy male volunteers were randomly divided into 2 groups.Double-periodical crossed design was used.The drug plasma concentration in 72 h was determined by microbioassay method.The relative bioavailability and related parameters of pharmacokinetics were calculated by DAS 2.0 program. Results The main pharmacokinetics parameters of the test preparation and the reference preparation were as follows:tmax were(7.3±2.6)h and(6.8±2.5)h;ρmax were(426.7±165.2)ng·L-1,(420.7±188.6)ng·L-1;t1/2 were(23.6±8.4)h,(28.5±7.0)h;AUC0-t were(9 568±3 265)ng·h·L-1,(9 398±3 733)ng·h·L-1;AUC0-∞ were(11 245±3 676)ng·h·L-1,(11 333±4 138)ng·h·L-1,respectively.The relative bioavailability of test to reference preparation was(105.0±19.3)%. Conclusions The test preparations are bioequivalent to the reference preparations." @default.
- W2355572575 created "2016-06-24" @default.
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- W2355572575 date "2011-01-01" @default.
- W2355572575 modified "2023-09-23" @default.
- W2355572575 title "Bioequivalence of mecobalamin soft capsules in human plasma" @default.
- W2355572575 hasPublicationYear "2011" @default.
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