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- W2355589514 abstract "[Objective]To investigate the effects of Zhihuang decoction on CD14 expression in LPS signal transduction pathway of alcohol-induced liver disease in rats.[Methods]Seventy five wistar rats were randomly divided into three groups.56% ethanol in the dose of 8 g/kg body weight was intragastricly administrated to 50 rats for ten days to make the model of alcohol-induced liver disease,and 25 of these 50 rats were treated with Zhihuang decoction simultaneously.All rats were sacrificed ten days later.The indexes of aspar-tateamino transferase(AST),alanine aminotransferase(ALT) were measured.The plasma content of endotoxin were assayed by biochemistry.The pathological changes in the liver was observed under light microscope with hematoxylin and eosin(HE) staining.RT-PCR method was applied to detect CD14 mRNA in liver and the expression of TNF-α in liver was tested by immune-histochemistry.[Results] Zhihuang decoction can alleviate the pathologic changes of liver.The level of endotoxin of the treatment group was higher than that of the normal group(P0.05),but significantly lower than that of the model group(P0.01).The level of TNF-α,ALT and AST was also higher than that of the normal group(P0.01),and significantly lower than that of the model group(P0.01).The expression of CD14mRNA in liver of the treatment group was also higher than that of the normal group(P0.05),but significantly lower than that of the model group(P0.01).[Conclusion ]Zhihuang decoction can markedly reduce the content of TNF-α and CD14mRNA expression in LPS signal transduction pathway,which is one of the most important mechanisms of Zhihuang decoction to treat hepatic injury induced by alcohol in rats." @default.
- W2355589514 created "2016-06-24" @default.
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- W2355589514 date "2008-01-01" @default.
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- W2355589514 title "Effect of Zhihuang decoction on CD14 expression in LPS signal transduction pathway of alcohol-induced liver disease in rats" @default.
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