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- W2355595770 abstract "Objective:To evaluate the effect of HLA-DQA1/DQB1 histocompatibility and lymphocyte immunotherapy(LIT) by using husband's lymphocyte or third-party lymphocyte on blocking antibody production of patients with recurrent miscarriage.Methods-.A total of 177 patients who met the criteria of unexplained recurrent miscarriage from October 2010 to June 2012 were enrolled in the study.All couples' HLA-DQAl and HLA-DQBl gene types were tested before treatment.The patients were immunized by husband's lymphocytes(140 patients)or third-party's lymphocytes(37 patients),depending on the results of husband's blood-borne diseases screening tests.Flow cytometry cross-match(FCXM) was used for evaluating anti-paternal lymphocyte antibody(APLA) and anti-third-party lymphocyte antibody(ATLA),before and after three times of treatment.Results:The couples with different HLA-DQA1 and HLA-DQB1 histocompatibility showed no significant difference(P0.05) in APLA production after treatment.APLA and ATLA were significantly higher after treatment than before treatment in both groups(P0.05).The APLA induced by husband's lymphocytes was significantly higher than ATLA induced by the third-party lymphocytes(P0.05).In the third-party treatment group,the level of ATLA was significantly higher than APLA after treatment(P0.05).Conclusions:HLA-DQA1/DQB1 histocompatibility had no effect on the blocking antibody production in lymphocyte immune therapy.The antibody production by using husband's lymphocyte therapy is better than that in third-party lymphocyte therapy." @default.
- W2355595770 created "2016-06-24" @default.
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- W2355595770 date "2013-01-01" @default.
- W2355595770 modified "2023-09-25" @default.
- W2355595770 title "Effect of HLA-DQA1/DQB1 histocompatibility and immunotherapy by using different source lymphocyte on blocking antibody production of patients with recurrent miscarriage" @default.
- W2355595770 hasPublicationYear "2013" @default.
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