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- W2355605076 abstract "Objective To study the influence of catalpol on early sensorimotor function and energy metabolism in rats with permanent cerebral ischemia injury.Methods The model of permanent focal cerebral ischemia of middle cerebral artery was established in rats and then randomly divided into the sham-operation group,model group,low-dose catalpol group,mid-dose catalpol group,high-dose catalpol group and Taponing group three days after the operation.All groups,except the sham-operation group,were given relevant medicinal intragastrically 3-14 days after the modeling.The performance of rats in the beam-walking test and adhesive plaster removing incubation were observed respectively at time points of 3 days,9 days and 14 days.The brain content of lactic acid and pyruvic acid were determined and the activities of Na+,K+-ATPase,Ca2+ and Mg2+-ATPase were detected 14 days after the operation.Results In the model group the performance of rats in the beam-walking test and adhesive plaster removing incubation were gradually improved along with time prolonging,but not recovered to normal level in most rats when 14-day observation period ended.These performance were improved significantly in all catalpol groups and Taponing group,especially in the mid-dose catalpol group and high-dose catalpol group(P0.05,P0.01).The content of lactic acid was decreased,the content of pyruvic acid was increased,and the activities of Na+,K+-ATPase,Ca2+,Mg2+-ATPase were improved in all catalpol groups and Taponing group and there was a significant difference compared with the model group(P0.01).Conclusion Catalpol can accelerate the recovery of sensorimotor function in rats with permanent cerebral ischemia injury,and the mechanism maybe related to the relief of symptoms of energy exhaustion." @default.
- W2355605076 created "2016-06-24" @default.
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- W2355605076 date "2011-01-01" @default.
- W2355605076 modified "2023-09-23" @default.
- W2355605076 title "Influence of catalpol on early recovery of sensorimotor function and energy metabolism in rats with permanent cerebral ischemia injury" @default.
- W2355605076 hasPublicationYear "2011" @default.
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