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- W2355611137 abstract "AIM: To clarify the effects of angiotensin-(1-7) on the calcification in rat vascular smooth muscle cells(VSMCs) and its signal transduction.METHODS: Calcification of cultured rat VSMCs was prepared by incubation of VSMCs with β-glycerophosphate. Calcification was confirmed by Von Kossa staining. The cells were treated with angiotensin-(1-7). The calcium content, alkaline phosphatases activity, osteocalcin and Cbfa1 mRNA expression were also measured.RESULTS: Angiotensin-(1-7) inhibited the increases of calcium content, alkaline phosphatases activity(P0.05), osteocalcin concentration and Cbfa1 mRNA expression in calcified VSMCs(P0.05), and the effects of angiotensin II on calcium content, alkaline phosphatases activity, osteocalcin concentration and Cbfa1 mRNA expression in calcified VSMCs were also inhibited (P0.05). Angiotensin-(1-7) increased cAMP concentration in calcified VSMCs(P0.05)and selective PKA inhibitor blocked the effects of angiotensin-(1-7) on calcium content, alkaline phosphatases activity, osteocalcin concentration and Cbfa1 mRNA expression(P0.05).CONCLUSION: Angiotensin-(1-7) can inhibit beta-glycerophosphate-induced calcification in VSMCs through cAMP-PKA-Cbfa1 pathway and antagonize the effect of angiotensin II on calcification in VSMCs." @default.
- W2355611137 created "2016-06-24" @default.
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- W2355611137 date "2007-01-01" @default.
- W2355611137 modified "2023-09-26" @default.
- W2355611137 title "Effects of angiotensin-(1-7) on calcification in vascular smooth muscle cells and its signal transduction pathway" @default.
- W2355611137 hasPublicationYear "2007" @default.
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