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- W2355615890 abstract "OBJECTIVE To analyze the platelet function change of hyperlipemia rats and evaluate the intervention effect of atorvastatin,losartan,compound Danshen dripping pills and prostaglandin E1 on the platelet function of them.METHODS Sixty-four Wistar rats were randomLy divided into six groups: control group,hyperlipidemic group,atorvastatin treated group(Ale,10 mg·kg-1·d-1),losartan treated group(Kesuya,20 mg·kg-1·d-1),compound Danshen dripping pills treated group(160 mg·kg-1·d-1) and prostaglandin E1 treated group(Kaishi,4 μg·kg-1·d-1).After four weeks of intervention,the serum levels of lipid(include CHO,TG,LDL-C and HDL-C) were measured.Euzymelinked immunosorbent assay was used to detect the serum levels of GMP140.Flow cytometric analysis was applied to detect the expression of CD62 on the surface of platelet.RESULTS The serum level of CHO,LDL-C,HDL-C/CHO,GMP140 and CD62P of control rats compared with those of hyperlipidemic subjects were 1.846 vs 13.779 mmol·L-1,0.164 vs 10.680 mmol·L-1,0.583 vs 0.195,10.665 vs 27.045 μg·L-1 and 10.089% vs 25.169%.The level of above-mentioned indicos of atorvastatin treated group were 7.053 mmol·L-1,4.659 mmol·L-1,0.312,13.371 μg·L-1 and 9.983%.Those of losartan treated group were 14.570 mmol·L-1,11.393 mmol·L-1,0.216,20.665 μg·L-1 and 20.144%.Indices of compound Danshen dripping pills treated and prostaglandin E1 treated group were 10.927 mmol·L-1,8.081 mmol·L-1,0.239,13.999 μg·L-1,10.476% and 14.962 mmol·L-1,11.074 mmol·L-1,0.255,21.040 μg·L-1,17.089% respectively.CONCLUSION Hyperlipidemic can enhance platelet activation.Atorvastatin can not only regulate dyslipidemia but also improve platelet function and refrain the activation of platelet.Losartan can refrain platelet activation too,So do compound Danshen dripping pills and prostaglandin E1.The improving platelet function effect of atorvastatin and compound Danshen dripping pills is better than that of losartan and prostaglandin E1.Atorvastatin and compound Danshen dripping pills resemble each other in the respect of refraining platelet activation,so do losartan and prostaglandin E1." @default.
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- W2355615890 date "2008-01-01" @default.
- W2355615890 modified "2023-09-25" @default.
- W2355615890 title "The intervention effect of atorvastatin,losartan,compound Danshen dripping pills and prostaglandin E_1 on the platelet function of hyperlipemia rats" @default.
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