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- W2355618923 abstract "Objective To explore possible poisonous and harmful effect of excessive iodine intake on skeleton in male rats. Methods Male rat models receiving various amounts of excessive iodine were established for 3,6, 12 months, and quantitative bone histomorphometric parameters and bone mineral density (BMD) of femur and lumbar spine( L1-1 ) were measured by means of dual-energy X-ray absorptimetry in vitro, and rats receiving normal diet were considered as control group. Results There was no significant difference in bone mineral quantity and structural parameters after feeding excessive iodine for 3 months in comparison with control group. The BMD of L1-4 was significantly increased in all animal groups when various amounts of excessive iodide was taken for 6 months (all P 0. 05). And quantitative bone histomorphometric parameters showed that the bone metabolism was in a vigorous state. After feeding excessive iodine for 12 months, BMD did not appear abnormal, whereas bone structural parameters-numbers of trabecular end were significantly increased ( all P 0.05) , suggested that iodine excess had led to trabecular split and destroyed normal bone structure. Conclusion The bone metabolism and structure are not seriously influenced by short-term excessive iodine intake in male rats, however, the bone structure appears to be destroyed by long-term intake of excessive iodine, suggesting that the toleration of iodine excess is limited in male rats." @default.
- W2355618923 created "2016-06-24" @default.
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- W2355618923 date "2006-01-01" @default.
- W2355618923 modified "2023-09-25" @default.
- W2355618923 title "Effect of excessive iodine intake on bone metabolism in male rats" @default.
- W2355618923 hasPublicationYear "2006" @default.
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