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- W2355634655 abstract "Objective: To explore the changes of in human hepatic carcinoma cells Hep-3B after bluetongue virus HbC_3(BTV-HbC_3) infection and their relationship with the BTV-HbC_3 induced apoptosis.Methods: Morphological changes of apoptosis and mitochondria of Hep-3B cells infected with BTV-HbC_(3)were observed under fluorescence microscope and transmission electron microscope.Mitochondrial function was assessed with MTT.The mitochondrial transmembrane potential of Hep-3B cells straining Rh123/PI and the apoptosis of Hep-3B cell staining Annexin V/PI were measured by flow cytometry(FCM).Results: Mitochondrial transmembrane potential and mitochondrial function of Hep-3B cells were significantly decreased at 24,36 and 48 hours after infection,but the rate of Hep-3B cells apoptosis markedly increased.Conclusion: BTV-HbC_(3)might inhibit the Hep-3B cells growth by inducing apoptosis and its mechanism might be related to the loss of △Ψm." @default.
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- W2355634655 date "2006-01-01" @default.
- W2355634655 modified "2023-09-27" @default.
- W2355634655 title "Role of Mitochondria in Human Hepatic Carcinoma Cell Apoptosis Induced by Bluetongue Virus HbC_3 Strain" @default.
- W2355634655 hasPublicationYear "2006" @default.
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