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- W2355637496 abstract "AIM:To investigate the solubilization of amphotericin B (AmB) by preparing poly (ethylene glycol)-poly(γ-benzyl-L-glutamate) (PEG-PBLG) nanoparticles and to evaluate their in vitro phagocytic uptake.METHODS:AmB-loaded PEG-PBLG nanoparticles were prepared by the dialysis.The AmB concentration was determined by HPLC assay;the uptake efficiency of pyrene-labeled PEG-PBLG nanoparticles was measured by fluorescence spectrometer.RESULTS:In the concentration range of 714.1～961.2 μg/mL, AmB could be solubilized in the nanoparticles dispersion solution of 0.2% (w/v) with PEG-PBLG having different average molecular weights.The concentration of AmB/PEG-PBLG nanoparticles was 85.0～114.4 folds higher than that of AmB in water.The uptake efficiency of Py-NP 99 with E/G ratio of 64 to 36 was about half of that of Py-NP 114 with E/G ratio of 33 to 76.Py-NP 99 could inhibit the adsorption of serum protein and escape the phagocytosis of mouse peritoneal macrophage.CONCLUSION:PEG-PBLG nanoparticles could solubilize AmB.The nanoparticles with higher E/G ratio could resist the phagocytosis more effectively than those with lower ratio." @default.
- W2355637496 created "2016-06-24" @default.
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- W2355637496 date "2005-01-01" @default.
- W2355637496 modified "2023-09-23" @default.
- W2355637496 title "In vitro Phagocytic Uptake Of PEG-PBLG Nanoparticles Containing Amphotericin B" @default.
- W2355637496 hasPublicationYear "2005" @default.
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