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- W2355638049 abstract "AIM:To explore the excision repair cross-complementing-1(ERCC1)expression level in human colorectal carcinoma,and analyze its relationship with the sensitivity of the platinum drugs and its prognosis.METHODS:Sixty-three archived samples of the patients with colorectal carcinoma were detected by immunohistochemical staining(Elivision).Forty-five patients underwent radical surgical treatment and 18 patients exploratory laparotomy.All patients were followed up for 6 years after the operation.Forty advanced cases with recurrence and metastasis received oxaliplatin-based chemotherapy.RESULTS:In these 63 patients,the positive expression rate of ERCC1was 52.08%,significantly lower than that in the control group.The positivity rate was correlated with colorectal cancer histologic grade(P=0.040).The histologic grade higher,the positive rate of ERCC1 lower,the expression intensity weaker.In using oxaliplatin cases,the response rate of the ERCC1 negative group was 60.00%(12/20),that of the ERCC1 positive group was 25.00%(5/20).There was significant correlation between the expression of ERCC1 and the efficacy of chemotherapy(P=0.025).The ERCC1 was an independent prognostic factor of colorectal cancer by the COX regression analysis(P=0.048).CONCLUSION:ERCC1 expression might be one of the prediction markers of the drug sensitivity of the platinum drugs and of prognosis in colorectal cancer." @default.
- W2355638049 created "2016-06-24" @default.
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- W2355638049 date "2008-01-01" @default.
- W2355638049 modified "2023-09-23" @default.
- W2355638049 title "Expression of ERCC1 in colorectal cancer and its clinical significance" @default.
- W2355638049 hasPublicationYear "2008" @default.
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