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- W2355642720 abstract "Objective To study the expressions of CD147 and matrix metalloprotease-9 in breast infiltrating duct carcinoma.Methods The expressions of CD147 and matrix metalloprotease-9 were examined in 60 cases of paraffin-embedded invasive ductal carcinoma tissue with immunohistochemcal staining SP method and 28 cases of invasive ductal carcinoma and adjacent freshly-taken tissues with Western blot.Results Immunohistochemistry showed that CD147 was mainly expressed in the membrane and the cytoplasm of cancer cells,and not expressed in the stroma.Matrix metalloprotease-9 was mainly expressed in the cytoplasm of cancer cells,and not expressed in the stroma.The expressions of CD147 and matrix metalloprotease-9 were correlated with histological grade and lymphatic metastasis(P0.05),and not correlated with age,tumor size and clinical stage(P0.05).The expression of two proteins had a significant correlation in invasive ductal carcinoma(r=0.769,P0.05).Western blot results showed that the expressions of two proteins were significantly higher in breast cancer than those in adjacent normal tissues(P0.05),and higher in lymphatic metastasis than in those without lymph node metastasis(P0.05).Conclusion The levels of CD147 and matrix metalloprotease-9 proteins in breast invasive ductal carcinoma increase significantly,which plays an important role in the development and progression of breast cancer." @default.
- W2355642720 created "2016-06-24" @default.
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- W2355642720 date "2012-01-01" @default.
- W2355642720 modified "2023-09-24" @default.
- W2355642720 title "Expressions of CD147 and matrix metalloprotease-9 in breast infiltrating duct carcinoma" @default.
- W2355642720 hasPublicationYear "2012" @default.
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