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- W2355647951 abstract "Objective To explore the association between single nucleotide polymorphisms(SNPs) at rs2308765 and rs9269186 sites of HLA-DRB1 gene and hypertensive nephropathy,and to provide theroretical basis for study on genetic mechanism of hypertensive nephropathy.Methods Case-control study method was used and 97 cases were collected in the study.PCR-LDR technique was used to detect the SNPs of HLA-DRB1 in 45 patients with hypertensive nephropathy and 52 controls.The goodness-of-fit χ2 test was used for Hardy-Weinberg equilibrium test in case and control groups.The differences of genotypic frequency and allelic frequency between case and control groups were test by χ2 test.Results There were G/T polymorphisms in rs2308765 sites,two genotypes G/G and G/T were found.The differences of genotype and allele distributions in rs2308765 between case and control were not significant(P0.05).There were C/G polymorphisms in rs9269186 sites,three genotypes C/C G/G and C/G were found.The differences of genotype and allele distributions in rs9269186 between case and control groups were significant(P0.05).Conclusion The correlation between SNPs at rs9269186 and hypertensive nephropathy is found,but not rs2308765." @default.
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- W2355647951 date "2012-01-01" @default.
- W2355647951 modified "2023-09-23" @default.
- W2355647951 title "Association between HLA-DRB1 gene polymorphisms and hypertensive nephropathy" @default.
- W2355647951 hasPublicationYear "2012" @default.
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