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- W2355659958 abstract "Objective To investigate the effect of Shh and Gli1 gene on the invasion,metastasis and prognosis of colon cancer.Methods Immunohistochemistry and RT-PCR method were used to evaluate the expression of Shh and Gli1 gene,and the relationship between its expression and the clinicopathological prognostic parameters was analyzed in 38 cades of colon cancer.Results There were high expression of Shh and Gli1 gene in colon cancer,the expression of Shh and Gli1 gene in colon cancer was elevated compare with their corresponding adjacent benign tissues.The expression of Shh and Gli1 gene in colon cancer was closly correlated to cancer staging,the expression of Shh and Gli1 gene in early-stage colon cancer was higher than that in advanced stage.Conclusion Abnormal active state of Shh signaling pathway maybe participate in the incidence of colon cancer,the detection of Shh and Gli1 gene take an important role in the assessment of colon cancer staging and prognosis." @default.
- W2355659958 created "2016-06-24" @default.
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- W2355659958 date "2011-01-01" @default.
- W2355659958 modified "2023-09-28" @default.
- W2355659958 title "Expression and Clinical Significance of Shh and Gli1 Gene in Colon Carcinoma Tissue" @default.
- W2355659958 hasPublicationYear "2011" @default.
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