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- W2355660944 abstract "Objective To study the expression and significance of proliferating cell nuclear antigen(PCNA) in diagnosis of carcinomatous conversion of oral mucosal epithelium.Methods S P immunohistochemical method was used to examine the expression of PCNA in 85 specimens of oral mucosal tissues including normal, mild dysplasia, moderate dysplasia, severe dysplasia and carcinoma.Results PCNA immunostaining in normal epithelim was limited to the basal layer with few positive cells in each specimen. As the lesions progessed, the positive expresion of PCNA accordingly increased and suprabasal PCNA positive reaction was found in dysplasia and carcinoma. The positive expression rate of PCNA in severe dysplasia was much higher than that in moderate dysplasia( P = 0.0008 ), While no significant difference of PCNA expression was found between severe dysplasia and carcinoma( P =0.7215).Conclusion The expression of PCNA has an important referential value in diagnosis of carcinomatous conversion of oral mucosal epithelium and may serve as an important biomarker for predicting the malignant change of oral mucosa." @default.
- W2355660944 created "2016-06-24" @default.
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- W2355660944 date "2000-01-01" @default.
- W2355660944 modified "2023-09-25" @default.
- W2355660944 title "SIGNIFICANCE OF THE EXPRESSION OF PCNA IN DIAGNOSIS OF CARCINOMATOUS CONVERSION OF ORAL MUCOSAL EPITHELIUM" @default.
- W2355660944 hasPublicationYear "2000" @default.
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