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- W2355663726 abstract "Objective:To evaluate the relationship between genetic polymorphisms of glutathione S-transferase mu (GSTM)1 and glutathione S-transferase theta (GSTT)1 and smoking and bladder cancer risk from a population-based case control study. Methods:The GSTM1 and GSTT1 genotypes were determined by multiplex PCR analysis in 414 bladder cancer patients and 404 population controls. The association between the genotypes and bladder cancer risk was measured by odds ratios (ORs) and 95% confidence intervals (95%CIs). The ORs and 95%CIs were calculated by unconditional logistic regression. Results:Compared with the GSTM1(+) genotypes,the GSTM1(-) genotype was associated with an increased risk of bladder cancer in men (OR:1.66,95%CI:1.18-2.33),but not in women (OR:1.08,95%CI:0.59-1.98). The increased risk of bladder cancer associated with GSTM(-) genotype was more apparent in smokers than that in nonsmokers. Compared with GSTM1(+) male nonsmokers, the ORs (95% CIs) were 2.99 (1.56-5.74) for current GSTM1(-) smokers and 4.33(2.14-8.73) for GSTM1(-) heavy smokers with smoking history of more than 40 years. Although few women smoked cigarettes,the risk of bladder cancer in GSTM1(-) female smokers was significantly elevated compared with GSTM1(+) female nonsmokers (OR:6.72,95%CI: 1.69-26.80). Compared with GSTT1(+) male non-smokers, the risk of bladder cancer in GSTT1(-) male smokers was increased (OR: 1.38, 95%CI:0.79-2.42). The risk of bladder cancer in GSTT1(-) female smokers was higher than GSTT1(+) female non-smokers (OR:3.04, 95%CI:0.77-12.01). Conclusion:GSTM1 null genotype was associated with an increased risk of bladder cancer,especially for smokers. GSTT1 genotypes might have no association with risk of bladder cancer in both male and female patients in urban Shanghai." @default.
- W2355663726 created "2016-06-24" @default.
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- W2355663726 date "2006-01-01" @default.
- W2355663726 modified "2023-09-30" @default.
- W2355663726 title "Polymorphisms of GSTM1 and GSTT1 with smoking and bladder cancer risk: a population-based case control study" @default.
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