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- W2355668460 abstract "Objective To study the antituberculosis effect of Yangshixinlaoning Capsule(YLN) on the ICR murine model with tuberculosis(TB).Methods A murine model infected with M.tuberculosis H37RV was established to study the anti-TB effect of YLN in vivo.Results Anti-TB experiment in vivo showed YLN had significant effect on ICR murine model.① ST50 of experiment groups respectively treated by YLN[1.0g/(kg·d),0.5g/(kg·d),0.25g/(kg·d)],especially 1.0g/(kg·d),was obviously longer than that of control group.Effect of all groups treated by YLN was no better than that of groups treated by the chemotherapeutic drugs.ST50 of group treated by YLN of higher dose was longer than that of group treated by Mao Zhua Cao.Survival rate of group treated by YLN combined with INH was higher than that of monotherapy model.②Body weight was obviously increased in groups with various dosage of YLN,especially in the goup with larger dose.Effect of monotherapy with YLN was no better than groups with the chemotherapeutic drugs,and effect of higher dose YLN was similar to that of Mao Zhua Cao group.Combination of YLN and INH resulted in much more body weight than mid-dose YLN group.③Except for liver pathogenic index in the low-dose YLN group,the organ pathogenic index in groups with various dosage of YLN was significantly decreased,especially high-dose YLN group.Effect of high-dose YLN group was better than that of Mao Zhua Cao,but liver pathogenic index of high-dose YLN group was similar to that of EMB group.Combination of INH and YLN was much better than monotherapy.Conclusion These results indicated that YLN,especially in higher doses,could improve the treatment outcome in ICR murine TB model." @default.
- W2355668460 created "2016-06-24" @default.
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- W2355668460 date "2007-01-01" @default.
- W2355668460 modified "2023-09-25" @default.
- W2355668460 title "Effect of Yangshixinlaoning Capsule on Tuberculosis in Murine Model" @default.
- W2355668460 hasPublicationYear "2007" @default.
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