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- W2355673434 abstract "OBJECTIVE To investigate pharmacokinetics of Panax notoginseng saponins(PNS) in Beagle dogs.METHODS PNS enteric-coated capsules 86.2 mg·kg-1 and Xueshuantong capsules 111.8 mg·kg-1 were administered to dogs according to an open randomized crossover design.The plasma concentration of notoginsenoside R1,ginsenoside Rg1 and Rb1 was determined by RP-HPLC.Pharmacokinetic parameters were calculated by 3P97 software so were those after the integration of blood concentration based on AUC0→∞.RESULTS Compared with reference preparation,tmax of test preparation R1,Rg1,Rb1 increased: 0.18±0.09 vs(0.16±0.06)h for R1,2.03±0.76 vs(1.74±0.27)h for Rg1,0.76±0.39 vs(0.74±0.17)h for Rb1;Lag times were prolonged: 0.96±0.16 vs(0.50±0.11)h for R1,0.87±0.05 vs(0.02±0.01)h for Rg1,0.92±0.12 vs(0.44±0.07)h for Rb1.The relative bioavailability of R1,Rg1,Rb1 and PNS was 248.41%,107.19%,152.94% and 155.31%,respectively.After integration,the main pharmacokinetic parameters of Xueshuantong capsules and PNS enteric-coated capsules respectively were: AUC0→t 39.17±3.89 vs(46.91±3.86)mg·L-1·h,Lag times 0.45±0.18 vs(0.93±0.13)h,tmax 0.74±0.17 vs(0.77±0.13)h,Cl3.84±0.24 vs(1.84±0.97)L·kg-1·h-1.CONCLUSIONPNS enteric-coated capsule can improve the oral bioavailability of PNS." @default.
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- W2355673434 date "2012-01-01" @default.
- W2355673434 modified "2023-09-25" @default.
- W2355673434 title "Pharmacokinetics of Panax notoginseng saponins enteric-coated capsules in Beagle dogs" @default.
- W2355673434 hasPublicationYear "2012" @default.
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