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- W2355678550 abstract "In a previous paper, changes in some physico-chemical properties of monoclonal antibodies (McAb) modified by PEG-1900 were described. In the present article, data on changes in biological properties of murine anti-TNP monoclonal antibodies (McAb) modified by PEG-1900 were presented. As a result of modification, the following changes in biological properties of PEG-modified McAb could be observed: ( 1 ) decrease in antibody activity, ( 2 ) decrease in antigeni-city and immunogenicity, ( 3 ) longer lasting time in blood circulation and ( 4 ) greater stability in the solution at higher temperature and in the solution at lower or higher pH. The modified antibodies moderately lost their activity whereas the enzyme modified in the same manner retained more than 69% activity of the native enzyme." @default.
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- W2355678550 date "1987-01-01" @default.
- W2355678550 modified "2023-09-25" @default.
- W2355678550 title "SOME BIOLOGICAL PROPERTIES OF MONOCLONAL ANTIBODIES MODIFIED BY POLYETHYAENE GLYCOL" @default.
- W2355678550 hasPublicationYear "1987" @default.
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