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- W2355700493 abstract "Objective: To evaluate the effect of the pilot-scale products of anti-caries DNA vaccine pGJA-P/VAX on inducing specific humoral immune response in mice.Methods: Anti-caries DNA vaccine pGJA-P/VAX were prepared by pilot-scale production in Wuhan Institute of Biologic Products,or extracted and purified using EndoFree Plasmid Maxi Kit in laboratory.Balb/c mice were immunized by both plasmids at week 0 and 2 by intramuscular injection or intranasal immunization.Flagellum protein was used as mucosal adjuvant,and pVAX1 was taken as control.Samples of serum and saliva were collected biweekly.The specific antibody levels were detected by quantitative ELISA.Results: Both the pilot-scale and laboratory products were able to induce specific antibody in serum in groups of intramuscular injection,but had limitations in inducing notable specific sIgA in saliva.While immunized together with flagellum protein,the pilot-scale plasmid was able to induce specific IgG in serum and sIgA in saliva.Compared to laboratory products under the same immunizing condition,the pilot-scale products induced weaker immune response,but with no significant differences.Conclusion: The pilot-scale products of anti-caries DNA vaccine pGJA-P/VAX was able to induce effective humoral immune response." @default.
- W2355700493 created "2016-06-24" @default.
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- W2355700493 date "2010-01-01" @default.
- W2355700493 modified "2023-09-24" @default.
- W2355700493 title "Experimental Study of the Pilot-scale Products of Anti-caries DNA Vaccine pGJA-P/VAX in Mice" @default.
- W2355700493 hasPublicationYear "2010" @default.
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