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- W2355711214 abstract "Objective To study the pathogenesis of posthaemorrhagic chronic hydrocephalus, the experimental models in pigs were founded. Methods 20 female GuiZhou's mini pigs were divided into controlled group (5 pigs) and experimental group (15 pigs). 15 experimental pigs by intraventricular infusion of 15ml、12ml and 8ml citrated autologous blood respectively, and the experimental models of posthemorrhagic chronic hydrocephalus were founded. The changes of pigs' ventricular dimension were observed with MRI and CSF circulation in subarachnoid space observed by SPECT. The changes of structures in pig's brains after intraventricular hemorrhage were investigated by light and electron microscopy. Results 1 pig (1/5) died in controlled group and 4 pigs (4/15) died in experimental group. In 30 days, chronic hydrocephaluses were found in 7 experimental pigs (7/11) , and no hydrocephaluses was found in controlled group. The persistently obstruction of CSF circulation and absorption in pigs subarachnoid space after intraventricular hemorrhage was detected. After hemorrhage, enlargement of subarachnoid space and augmented fibrous tissues in arachnoid space of pigs' brains were found, and these changes were less obvious in non- hydrocephalus pigs. Conclusions The obstruction of CSF circulation and absorption might be derived from arachnoid fibrosis, and subarachnoid fibrosis might be the major cause of posthemorrhagic chronic hydrocephalus." @default.
- W2355711214 created "2016-06-24" @default.
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- W2355711214 date "2007-01-01" @default.
- W2355711214 modified "2023-09-24" @default.
- W2355711214 title "The foundation of the experimental models of posthemorrhagic chronic hydrocephalus and the changes of CSF circulation in subarachnoid space after intraventricular hemorrhage in pigs" @default.
- W2355711214 hasPublicationYear "2007" @default.
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