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- W2355715990 abstract "Aim: To further elucidate the possible mechanisms of gastric cardia carcinogenesis and the relationship between alterations of MUC3 and lesion progress on the subjects from HIA and LIA for GCC.Methods: Immunohistochemistry (ABC) and morphological analysis method were undertaken to determine the expression of MUC3 in gastric cardia carcinogenesis. 166 biopsies with different lesions were selected randomly from the mass survey data bank (63 from the HIA, 103 from the LIA). 109 surgical resected GCA specimens (70 from the HIA, 39 from the LIA) were also collected for the study. Results: In the HIA, with the lesions progressed from CSG→CAG→DYS→GCA, the positive rates of MUC3 expression were 13%, 44%, 29% and 38%, respectively, espercially the highest is in the stage of GCA; In the LIA, with the lesions progressed from CSG→CAG→DYS→GCA, an increasing tendency of MUC3 expression was observed, and the positive expression rates were 13%, 13%, 50% and 33%, respectively, espercially the highest is in the stage of DYS. Conclusion: In contrast with the population at the HIA,where the highest rate of MUC3 positive immunostaining is in the stage of GCA, a remarkable increasing tendency for MUC3 positive immunostaining was observed with the lesions progression from the population at the LIA, especially in the stage of DYS. This difference indicated that there may be some different mechanism in gastric cardia carcinogenesis at different area." @default.
- W2355715990 created "2016-06-24" @default.
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- W2355715990 date "2003-01-01" @default.
- W2355715990 modified "2023-09-28" @default.
- W2355715990 title "Alterations of C-erbB2 in gastrocardia precancerous and cancerous lesions: a comparative study between the high-and low-risk populations" @default.
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