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- W2355725065 abstract "Objective:To evaluate the association between the mismatch repair gene hMLH1-93GA promoter polymorphism and risk of gastric cancer in a population of Jiangsu province in China. Methods:Total of 554 patients with gastric cancer cases and 582 cancer-free controls frequency-matched by age (±5)and sex were recruited in the study. The genotypes of the hMLH1-93GA polymorphism were detected by TaqMan MGB probe method. We further assessed its association with risk of gastric cancer and interaction with tumor clinic pathological characteristics. Results:There was no significant association of the frequencies of GA or AA among the case and control groups,for case group:GA 262(47.3%),AA 187(33.8%); for control group:GA 269(46.2%),AA 190(32.7%);P= 0.636 and 0.398,respectively. The variant genotypes(GA+AA) did not significantly increase the risk of gastric cancer,compared with the GG genotype[adjusted odds ratio(OR)=1.11,95% confidence interval(CI)=0.82～1.51,P=0.487]. No significant association was observed between the variant genotypes of the hMLH1-93GA polymorphism and the clinic pathological characteristics in gastric cancer. Conclusion:There was no significant association between the hMLH1-93GA polymorphism and gastric cancer susceptibility." @default.
- W2355725065 created "2016-06-24" @default.
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- W2355725065 date "2010-01-01" @default.
- W2355725065 modified "2023-09-28" @default.
- W2355725065 title "The association between hMLH1-93G>A promoter polymorphism and risk of gastric cancer" @default.
- W2355725065 hasPublicationYear "2010" @default.
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