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- W2355743670 abstract "Objective To observe the influence of PTHrP1-34 on the bone metabolism and tumor growth in mice.Methods Thirty six female healthy mice were included in this study.The mice were divided into control,model and experimental groups,12 mice in each group.The mice in model and experimental groups were injected with suspension of human breast cancer MDA-MB-231 cells or inoculated with tumor tissue pieces.10 days later,the mice of model group were injected with physiological saline intraperitoneally every day,and the mice of experimental group received PTHrP 400 μg/kg once per day,for 35 consecutive days.The whole body bone mineral density(BMD),ratio of ash weight to dry weight and bone metabolism-related parameters such as serum calcium(Ca),phosphor(P),alkaline phosphatase(ALP),osteocalcin(OC),Collagen type I cross-linked C-telopeptide β(β-CTX),bone sialoprotein(BSP) were assayed and the tumor sizes and weights were compared.Results Serum Ca level of different groups showed no statistically significant differences(P0.05).Compared with the other two groups,P,β-CTX and BSP levels of the experimental group were significantly increased(P0.01 or P0.05),and the ALP and BGP levels were significantly reduced(P0.01 or P0.05).BMD and the ratio of ash weight to dry weight were significantly reduced(P0.01).There was no significant difference between the control group and model group(P0.05).The tumor size and weight of experimental group were significantly higher than those of the model group.Conclusion Under the action of PTHrP1-34,bone resorption is greater than bone formation,leading to osteolytic destruction and reduced bone mineral density.In addition,some cytokines released during the bone destruction may promote the tumor growth." @default.
- W2355743670 created "2016-06-24" @default.
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- W2355743670 date "2009-01-01" @default.
- W2355743670 modified "2023-09-25" @default.
- W2355743670 title "Destructive Effect of PTHrP1-34 on Bone Metabolism and Tumor Growth in Mice" @default.
- W2355743670 hasPublicationYear "2009" @default.
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