Matches in SemOpenAlex for { <https://semopenalex.org/work/W2355746194> ?p ?o ?g. }
Showing items 1 to 59 of
59
with 100 items per page.
- W2355746194 abstract "Objective: To explore the effects o f l-THP (l-tetrahydropalmatine) on drugs with psychic dependence producing poten tial. Methods:The rats were trained to discriminate morphine (2.50 mg·kg -1) from saline under fixed-ratio schedule and after the dis crimination established, morphine of different doses(0.31、0.63、1.25、2.50 mg·kg -1) was given to substitute for the training dose. Then, the rats we re administered with DA receptor antagonists Sch23390, raclopride and l-THP (1. 25、2.50、5.00 mg·kg -1), respectively to antagonize the effect. Results:The rats acquired morphine discrimination at the dose of 2 .50 mg·kg -1 and the effect was antagonized by Sch23390, raclopride a nd l -THP, and l-THP could dose-dependently antagonize the effects of morphine. Conclusion:The rats can steadily discriminate morphine from salin e and DA receptors are involved in this effect. The effect of l-THP on the discr iminative stimulus suggests that l-THP can inhibit the psychic dependence of mor phine." @default.
- W2355746194 created "2016-06-24" @default.
- W2355746194 creator A5017402123 @default.
- W2355746194 date "2005-01-01" @default.
- W2355746194 modified "2023-09-25" @default.
- W2355746194 title "THE EFFECTS OF l-THP ON MORPHINE-INDUCED DISCRIMINATION" @default.
- W2355746194 hasPublicationYear "2005" @default.
- W2355746194 type Work @default.
- W2355746194 sameAs 2355746194 @default.
- W2355746194 citedByCount "0" @default.
- W2355746194 crossrefType "journal-article" @default.
- W2355746194 hasAuthorship W2355746194A5017402123 @default.
- W2355746194 hasConcept C126322002 @default.
- W2355746194 hasConcept C134018914 @default.
- W2355746194 hasConcept C170493617 @default.
- W2355746194 hasConcept C185592680 @default.
- W2355746194 hasConcept C2776885963 @default.
- W2355746194 hasConcept C2777389121 @default.
- W2355746194 hasConcept C2777397205 @default.
- W2355746194 hasConcept C2781069445 @default.
- W2355746194 hasConcept C71924100 @default.
- W2355746194 hasConcept C98274493 @default.
- W2355746194 hasConceptScore W2355746194C126322002 @default.
- W2355746194 hasConceptScore W2355746194C134018914 @default.
- W2355746194 hasConceptScore W2355746194C170493617 @default.
- W2355746194 hasConceptScore W2355746194C185592680 @default.
- W2355746194 hasConceptScore W2355746194C2776885963 @default.
- W2355746194 hasConceptScore W2355746194C2777389121 @default.
- W2355746194 hasConceptScore W2355746194C2777397205 @default.
- W2355746194 hasConceptScore W2355746194C2781069445 @default.
- W2355746194 hasConceptScore W2355746194C71924100 @default.
- W2355746194 hasConceptScore W2355746194C98274493 @default.
- W2355746194 hasLocation W23557461941 @default.
- W2355746194 hasOpenAccess W2355746194 @default.
- W2355746194 hasPrimaryLocation W23557461941 @default.
- W2355746194 hasRelatedWork W1964996891 @default.
- W2355746194 hasRelatedWork W1982942910 @default.
- W2355746194 hasRelatedWork W1986589960 @default.
- W2355746194 hasRelatedWork W2000543816 @default.
- W2355746194 hasRelatedWork W2043067657 @default.
- W2355746194 hasRelatedWork W2059378067 @default.
- W2355746194 hasRelatedWork W2062583335 @default.
- W2355746194 hasRelatedWork W2064222199 @default.
- W2355746194 hasRelatedWork W2074201173 @default.
- W2355746194 hasRelatedWork W2075450004 @default.
- W2355746194 hasRelatedWork W2086986998 @default.
- W2355746194 hasRelatedWork W2319571914 @default.
- W2355746194 hasRelatedWork W2369289864 @default.
- W2355746194 hasRelatedWork W2384539721 @default.
- W2355746194 hasRelatedWork W2400053685 @default.
- W2355746194 hasRelatedWork W2406647623 @default.
- W2355746194 hasRelatedWork W2410853092 @default.
- W2355746194 hasRelatedWork W3131848620 @default.
- W2355746194 hasRelatedWork W314712205 @default.
- W2355746194 hasRelatedWork W2593727619 @default.
- W2355746194 isParatext "false" @default.
- W2355746194 isRetracted "false" @default.
- W2355746194 magId "2355746194" @default.
- W2355746194 workType "article" @default.