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- W2355747470 abstract "Objective To evaluate the neuroprotection of memantine against cerebral ischemia in SD rat models,and investigate the underlying mechanism.Methods Rats were randomly assigned to 4 groups: sham-operation group,ischemia/reperfusion group,vehicle control group and drug test group.Transient brain ischemia(15 min) and reperfusion was induced by the four-vessel occlusion method(4-VO).The experiment was performed by using IB,IP and morphologic methods to examine the expression of relevant message proteins and the survival of hippocampal neurons.Results Transient cerebral ischemia/reperfusion induced obvious neuronal death,which could be improved by the use of memantine.It was also found that memantine inhibited the interactions between NR2A,Src and PSD-95,and decreased the tyrosine phosphorylation of NR2A.Conclusions The neuroprotective effects of memantine against cerebral ischemic/reperfusion damage are pathologically confirmed in SD rats models.And the mechanism may involve the tyrosine phosphorylation of NR2A by Src." @default.
- W2355747470 created "2016-06-24" @default.
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- W2355747470 date "2008-01-01" @default.
- W2355747470 modified "2023-09-22" @default.
- W2355747470 title "Pathological study on the neuroprotection of memantine against cerebral ischemia in SD rats" @default.
- W2355747470 hasPublicationYear "2008" @default.
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