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- W235574928 abstract "Abstract : RDX is found in soil and ground water in and surrounding training ranges, creating potential hazards to human health. Oral RDX over-exposure causes seizure in rats and humans, the mechanism of which is unknown. In this study rats were dosed orally at 75 mgkg RDX to induce seizure. The brain concentration of RDX was determined in samples taken from rats euthanized at the time of seizure onset: brain acetylchohnesterase was also measured. Also. RDX was screened for affinity to a library of brain receptors to determine if RDX affected any seizure-related targets. Brain concentration: of RDX were greater than S ug/g wet wt. in the animals that seized RDX was found to bind exclusively to the convulsant site on the GABAa receptor with an IC50 of 22 microM. The mechanism of RDX-induced seizure is likely due to dis-inhibition of excitatory neurons by blockage of the GABA-niediated inhibitory chloride current. This valuable information contributes mode of action insights that can be used in the physiologically-based pharmacokinetic modeling to extrapolate rat data to human." @default.
- W235574928 created "2016-06-24" @default.
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- W235574928 date "2009-09-01" @default.
- W235574928 modified "2023-09-24" @default.
- W235574928 title "Mechanism of RDX-Induced Seizures in Rats" @default.
- W235574928 hasPublicationYear "2009" @default.
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