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- W2355756032 abstract "AIM: To establish a canine model of fat embolism-induced no/slow flow of coronary artery for the study of the involvement of fat embolism in the pathogenesis of interventional slow/no flow.METHODS: Twenty hybrid dogs were subjected to left ventricular imaging and coronary angiography as well as hemodynamic parameter measurement at baseline.Intracoronary infusion of fat emboli was accomplished to produce slow/no flow of the dominant coronary artery,which was confirmed by coronary angiography.Electrocardiogram(ECG) and vital signs were recorded throughout the procedures.RESULTS: Seventeen dogs survived the procedure and 15 met the standard of coronary angiography for slow/no flow in animal models,i.e.,TIMI flow grade ≤II and corrected TIMI frame count(CTFC)≥36.2.Overall success rate was 75%.After the establishment of slow/no flow model,the heart rate increased rapidly,blood pressure decreased and left ventricular systolic pressure significantly decreased(P0.05).During the process,ECG showed similar evolvement as that of acute myocardial injury and reperfusion.CONCLUSION: Intracoronary injection of ultraselected fat is a good way to produce canine models of slow/no flow during percutaneous coronary intervention." @default.
- W2355756032 created "2016-06-24" @default.
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- W2355756032 date "2010-01-01" @default.
- W2355756032 modified "2023-09-28" @default.
- W2355756032 title "Establishment of a canine model of fat embolism induced no/slow flow of coronary artery" @default.
- W2355756032 hasPublicationYear "2010" @default.
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