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- W2355757799 abstract "Objective To investigate the effects of cell cycle and apoptosis by photodynamic therapy on human colon carcinoma cell transfected with cytosine deaminase gene.Methods:On the basis of SW480 colon carcinoma cell culture,CD suicide gene was transfected into SW480 cell,and then to investigate the effects of SW480 cell cycle and apoptosis by flow cytometer.Results:The decreasing G1,phase cells,increasing S phase cells were observed significantly in group PDT after 24 hours and 12 hours respectively as compared with that of the control(P0.01).The cell cycle distribution of group PDT+CD/5-Fc has no significantly difference as compared with that of the control(PO.05).But increasing apoptosis ratio was observed in group PDT+CD/5-Fc as compared with that of the control(P0.01).Conclusion:G1 phase cells maybe more sensitive to PDT than that of S phase cells in our experiment.G1 phase cells and S phase cells maybe both sensitive to PDT+CD/5-Fc.PDT combination with CD/5-Fc suicide gene could induce much more apoptosis ratio in SW480-CD cells." @default.
- W2355757799 created "2016-06-24" @default.
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- W2355757799 date "2007-01-01" @default.
- W2355757799 modified "2023-09-23" @default.
- W2355757799 title "The effects of cell cycle and apoptosis by photodynamic therapy on human colon carcinoma cell transfected with cytosine deaminase gene" @default.
- W2355757799 hasPublicationYear "2007" @default.
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