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- W2355758512 abstract "Objective To investigate the role of p38 mitogen activated protein kinase(p38MAPK)in SHSY5Y cell injury caused by beta-amyloid(Aβ)and oxygen glucose deprivation(OGD).Methods The SHSY5Y neuroblastoma cells were exposed to OGD,with or without Aβ(5 μmol/L).The cell viability was detected by the MTT assay,activity of p38MAPK was detected by Western blot method,and intracellular concentration of calcium was evaluated via the fluorescence intensity of fluo 3/AM.Results Compared with the control group,the MTT value was(63±4)%,(68±7)%,(56±1)% in the OGD,Aβ and OGD+Aβ groups respectively,significantly lower than that that in control group(P0.05 or P0.01).The activity of p38MAPK was(121±3)%,(132±4)%,(165±5)% in the OGD,Aβ and OGD+Aβ groups respectively,significantly higher than that in control group(P0.05 or P0.01).The fluorescence intensity of fluo 3/AM was(169±4)%,(176±4)%,(220±7)% in the OGD,Aβ and OGD+Aβ groups respectively,significantly higher than that in the control group(P0.05 or P0.01).Conclusion It showed that OGD+Aβ caused SHSY5Y cells injury was greater than the OGD and Aβ groups.The possible mechanisms seemed to enhancement the activity of p38MAPK,and then disturbed calcium homeostasis,result in the apoptosis of SHSY5Y cells." @default.
- W2355758512 created "2016-06-24" @default.
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- W2355758512 date "2009-01-01" @default.
- W2355758512 modified "2023-09-24" @default.
- W2355758512 title "The role of p38 mitogen activated protein kinase in SHSY5Y cell injury caused by beta amyloid and oxygen glucose deprivation" @default.
- W2355758512 hasPublicationYear "2009" @default.
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