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- W235576657 abstract "Background: Increased rates of major adverse cardiovascular events following percutaneous coronary intervention (PCI) in individuals receiving clopidogrel have been associated with the CYP2C19*2 allele. Ultra rapid identification of CYP2C19*2 carriers with subsequent alteration of anti-platelet therapy would be integral for development of pharmacogenomic strategies. To date, there has been no prospective evaluation of this strategy. Methods: We developed and validated a point-of-care genetic test for the CYP2C19*2 allele and then evaluated its feasibility in the clinical setting through a prospective proof-of-concept randomized controlled trial designed to examine the potential efficacy of a pharmacogenomic approach following PCI. Patients were randomized to either a strategy of rapid genotyping with selective administration of prasugrel 10mg daily to CYP2C19*2 carriers or to standard therapy with clopidogrel 75 mg daily. Efficacy of the treatment strategies was evaluated using platelet function testing w..." @default.
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- W235576657 date "2011-11-22" @default.
- W235576657 modified "2023-10-12" @default.
- W235576657 title "Abstract 14288: ReAssessment of Anti-Platelet Therapy Using an Individualized Strategy Based on Genetic Evaluation Facilitated by a Point-Of-Care Genetic Test (RAPID GENE): A Randomized Proof-Of-Concept Study" @default.
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