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- W2355772517 abstract "Objective To explore the effect of cardiotrophin-1(CT-1),AG490(an inhibitor of JAK) and tetramethylpyrazine(TMP) in the angiotensin Ⅱ(Ang Ⅱ)-induced myocardial cells hypertrophy.Methods Myocardial cells hypertrophy was induced by Ang Ⅱ stimulation.Then transfection with the CT-1 antisense oligodeoxynucleotide(ASODN) or AG490 and TMP was given to the myocardial cells.Myocardial cells sizes and 3H-leucine incorporation were exmained to evaluate myocardial hypertrophy,and RT-PCR was used to detect CT-1 mRNA expression.Results After Ang Ⅱ stimulation,myocardial cells size,3H-leucine incorporation and CT-1 mRNA expression were increased.Myocardial cells size,3H-leucine incorporation and expression of CT-1 mRNA were decreased in the ASODN group.In the AG490 and TMP group,myocardial cells size and 3H-leucine incorporation were decreased without the effection of the CT-1 mRNA expression.Conclusion CT-1 has relationship with myocardial cells hypertrophy;ASODN,AG490,TMP could inhibit Ang Ⅱ-induced myocardial cells hypertrophy." @default.
- W2355772517 created "2016-06-24" @default.
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- W2355772517 date "2012-01-01" @default.
- W2355772517 modified "2023-09-24" @default.
- W2355772517 title "Inhibitory effect of cardiotrophin-1 antisense oligonucleotide,AG490 and tetramethylpyrazine on cardiomyocyte hypertrophy induced by angiotensin II" @default.
- W2355772517 hasPublicationYear "2012" @default.
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