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- W2355797169 abstract "Objectives To elucidate the role of Salvia Miltiorrhiza(SM) for the treatment and prevention in diabetic retinopathy(DR) and investigate the underlying mechanism.Methods 40 male Wistar rats were randomly divided into five groups:control group;diabetes for 1 month(DM1);diabetes for 3 month(DM3);diabetes treated with SM for 1 month(SM1) and diabetes treated with SM for 3 month(SM3).The diabetic rats model was induced by the peritoneal injection of streptozotocin(60 mg/kg).Treatment group were injected with SM(20 mg/kg/d).Light and electron microscope,computer picture quantitative analysis and RT-PCR were adopted to observe the changes of retinal ultrastructure and the expression of Vascular endothelial growth factor(VEGF) in different groups.Results In treatment group with SM,the retinal ganglion cells and nuclear layer cells increased remarkably compared to control and diabetic groups.The retinal structure was improved obviously.There was no significant difference of VEGFmRNA expression among different groups.Conclusion SM could effectively prevent and cure DR,and its mechanism maybe related to improving anoxic condition and reducing oxidative stress." @default.
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- W2355797169 date "2011-01-01" @default.
- W2355797169 modified "2023-09-23" @default.
- W2355797169 title "Preventive and therapeutic effect of Salvia Miltiorrhiza for diabetic retinopathy" @default.
- W2355797169 hasPublicationYear "2011" @default.
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