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- W2355802010 abstract "Objective: To investigate the clinical significance of serum NO 2- and cyclic guanosine monophosphate (cGMP) levels to diagnose preterm delivery. Methods: 322 pregnant women were enrolled, including 240 normal pregnancies、30 normal full-terrn delivery women, and 52 preterm pregnancies. The serum NO 2- and cGMP levels were examined by oscillopolarography and radioimmunoassay. Results: The serum NO 2- and cGMP levels gradually increased from 28 to 36 +6gestational weeks in normal pregnancy, then they gradually decreased in the term and post-partum. The highest serum NO 2- and cGMP levels were observed in 34～34 +6 and 33～33 +6 gestational weeks, respectively. The serum NO 2- and cGMP levels in full-term pregnancies were significantly lower than fhose in 33～33 +6,35～35 +6,and 36～36 +6 gestational weeks (P0.05 and P0.005,respectively). The serum NO 2- and cGMP levels in preterm pregnancy were significant decreased when compared to those in the normal pregnancy (P0.001, P0.05). The sensitivity and specificity of serum NO 2- and cGMP levels to diagnose preterm delivery were 86.36%、80% and 82.12%、78.56% respectively. Conclusions: These data suggesed that it may be useful to detect the serum NO 2- and cGMP levels to diagnose preterm delivery. More experiments should be carried out in the following study.[" @default.
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- W2355802010 date "2004-01-01" @default.
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- W2355802010 title "Significance of the Serum NO_2~- and Cyclic Guanosine Monophosphate Levels toDiagnose of Preterm Delivery" @default.
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