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- W2355806530 abstract "Objective To evaluate the surgical technique and the outcome of 125I interstitial implantation for pancreatic carcinoma and the treatment for normal pancreatic tissue radiation damage. Methods Twenty-seven patients with biopsy proven unresectable adenocarcinoma of pancreas were treated with 125I implants during laparotomy. The survival rate, effective rate and relative factors of patients after treatment were compared and studied; 24 rabbits were divided into groups A B. Normal pancreatic tissue and margins of mesenteric blood vessel were implanted with 125I seeds. The animals were sacrificed after 40 and 80 days respectively. HE staining was used to evaluate the chronic radiation injury to pancreas and blood vessel. Results ⑴The effective rate of 125I brachytherapy showed that there were 2 CR cases (8%); 8 PR cases (32%); 12 SD cases (48%) and 3 PD cases (12%) with pain relief in 92%. The 6, 12 and 18-month actuarial overall survival rates were 81%,29% and 7% respectively. The median survival time was 11.2 months. Overall survival was better for patients with smaller volume implants, a lower total activity implanted and postoperative radiation therapy. Pancreatitis occurred in 2 cases (7.4%); ⑵The chronic radiation injury to rabbit pancreas showed a gradual repairing tendency. The impairment of endothelial cell appeared later and the denaturation of muscular layer was obviously restored. Conclusions 125I radioactive seed implantation was safe. A high local control, minimal damage and satisfactory pain palliation could be achieved without significant complications for malignant pancreatic tumor." @default.
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- W2355806530 date "2009-01-01" @default.
- W2355806530 modified "2023-09-22" @default.
- W2355806530 title "125)I implantation for unresectable pancreatic carcinoma and empirical study of normal pancreatic tissue radiation damage" @default.
- W2355806530 hasPublicationYear "2009" @default.
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